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  • Chemical Biology

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    Here’s some medicinal chemistry combined with synthetic biology for you. Many people are used to thinking in terms of finding small-molecule probes for various cell targets, and those are valuable things. But what if you want to control a certain population of (for example) ion channels, but there aren’t any compounds that will do the… Geo Shawl Wrap Very Soft Wool Blend Throw Fashionable Lap Winter Scarf New
  • Chemical News

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    J.S Hanger 10 Tier Hanging Organizer Set of 2 I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Georgia Blanket with Fleece Reverse - Double Queen Bed - Pink & White
  • Analytical Chemistry

  • Cancer

  • Drug Assays

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    Jekeno Unicorn Throw Blanket Smooth Soft Blanket for Sofa Clair Bed Office A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

  • Business and Markets

  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… Glass Tea Light Candle Holders Lot Of 70
  • Academia (vs. Industry)

    Startup Culture, Starting

    John Deere tractors Fleece throw blanket 48X63 model 40 new farm bedding new JD Many readers of this blog work in the biopharma industry, naturally, and of those, many are in and around the (few) locations where a great many of the companies in the industry are born. I myself am in the Boston/Cambridge area, famously thick with companies large and small, and then you have the Bay area… Glitz Triple Reindeer 3 tealight holder (Set of 2) - Big Living
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